The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned
chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a …

Signaling pathways that respond to DNA damage are essential for the maintenance of genome
stability and are linked to many diseases, including cancer. Here, a genome-wide siRNA …

Stochasticity inherent to biochemical reactions (intrinsic noise) and variability in cellular
states (extrinsic noise) degrade information transmitted through signaling networks. We …

Background The pole-to-pole distance of the metaphase spindle is reasonably constant in a
given cell type; in the case of vertebrate female oocytes, this steady-state length can be …

Recently, we have shown that a cancer causing truncation in adenomatous polyposis coli (APC)
(APC 1–1450 ) dominantly interferes with mitotic spindle function, suggesting APC …

Social insects exhibit coordinated behaviour without central control. Local interactions among
individuals determine their behaviour and regulate the activity of the colony. Harvester …

Recently, there has been a surge in the number of pioneering studies combining experiments
with quantitative modeling to explain both relatively simple modules of molecular …

Background Mitosis depends upon the cooperative action of multiple microtubule (MT)-based
motors. Among these, a kinesin-5, KLP61F, and the kinesin-14, Ncd, are proposed to …

Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm
to the nucleus. Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help …

Among a number of innovative approaches that have modernized cell biology, modeling
has a prominent yet unusual place. One popular view is that we progress linearly, from …