The tumor microenvironment strongly influences cancer development, progression, and
metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their …

Background In South China (Gejiu City, Yunnan Province), lung cancer incidence and
associated mortality rate is the most prevalent and observed forms of cancer. Lung cancer in this …

Malignant melanoma is one of the most aggressive malignancies in human and is
responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white …

Integrin α11 (ITGA11/α11) is localized to stromal fibroblasts and commonly overexpressed
in non-small-cell lung carcinoma (NSCLC). We hypothesized that stromal α11 could be …

Malignant melanoma is one of the most aggressive malignancies in humans and is responsible
for 60–80% of deaths from skin cancers. The 5-year survival of patients with metastatic …

Carcinoma-associated fibroblasts (CAF) represent a significant component of pancreatic
cancer stroma and are biologically implicated in tumor progression. However, evidence of both …

Fibroblast activation protein (FAP) is a cell-surface serine protease highly expressed on
cancer-associated fibroblasts of human epithelial carcinomas but not on normal fibroblasts, …

The receptor for the type 1 insulin-like growth factor (IGF-1R) plays a critical role in the acquisition
of the malignant phenotype. Using a highly metastatic murine lung carcinoma model, it …

Abelson interactor protein-1 (ABI-1) is an adaptor protein involved in actin reorganization
and lamellipodia formation. It forms a macromolecular complex containing Hspc300/WASP …

Polarization second harmonic microscopy was used for collagen imaging in human non-small
cell lung carcinoma and normal lung tissues ex vivo and revealed significant differences …