User profiles for Ru-Rong Ji
 | Ru-Rong JiProfessor of Anesthesiology and Neurobiology, Duke University Verified email at duke.edu Cited by 48769 |
Central sensitization and LTP: do pain and memory share similar mechanisms?
Synaptic plasticity is fundamental to many neurobiological functions, including memory and
pain. Central sensitization refers to the increased synaptic efficacy established in …
pain. Central sensitization refers to the increased synaptic efficacy established in …
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
We investigated the involvement of extracellular signal-regulated protein kinases (ERK) within
spinal neurons in producing pain hypersensitivity. Within a minute of an intense noxious …
spinal neurons in producing pain hypersensitivity. Within a minute of an intense noxious …
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
M Matsuda, Y Huh, RR Ji - Journal of anesthesia, 2019 - Springer
Inflammation is the body’s response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity,
and increased neuronal responsiveness in central pain pathways after painful insults. …
and increased neuronal responsiveness in central pain pathways after painful insults. …
Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain
Pathological pain, consisting of tissue injury-induced inflammatory and nerve injury-induced
neuropathic pain, is an expression of neuronal plasticity. One component of this is that the …
neuropathic pain, is an expression of neuronal plasticity. One component of this is that the …
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent …
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent …
Glia and pain: is chronic pain a gliopathy?
Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
MAP kinase and pain
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
[HTML][HTML] p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
Peripheral inflammation induces p38 MAPK activation in the soma of C fiber nociceptors in
the dorsal root ganglion (DRG) after 24 hr. Inflammation also increases protein, but not …
the dorsal root ganglion (DRG) after 24 hr. Inflammation also increases protein, but not …
Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1β, interleukin-6, and tumor necrosis factor-α in regulating synaptic and …
Y Kawasaki, L Zhang, JK Cheng, RR Ji - Journal of neuroscience, 2008 - Soc Neuroscience
Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries,
plays an essential role in the induction and maintenance of chronic pain. However, synaptic …
plays an essential role in the induction and maintenance of chronic pain. However, synaptic …