Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1%
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …

The corpus cavernosum is the most important structure for penile erection, and its
dysfunction causes many physiological and psychological problems. However, its cellular …

Generation of functional spermatids from azoospermia patients is of unusual significance in
the treatment of male infertility. Here, we report an efficient approach to obtain human …

Many infertile men are the victims of spermatogenesis disorder. However, conventional
clinical test could not provide efficient information on the causes of spermatogenesis disorder …

MicroRNAs (miRNAs) play important roles in mammalian spermatogenesis, which is highly
dependent on Sertoli cells. However, the functions and mechanisms of miRNAs in regulating …

STUDY QUESTION Are there differences in the morphology, spectrum and biochemical
phenotype between Sertoli cells from non-obstructive azoospermia (NOA) patients and those …

Generation of germ cells from pluripotent stem cells in vitro could have great application for
treating infertility and provides an excellent model for uncovering molecular mechanisms …

We have previously shown that the transcript levels of Vegfc and its receptor Vegfr3 were
high in spermatogonia and extremely low in spermatocytes and spermatids. However, it …

Background Sertoli cells are the most important somatic cells contributing to the
microenvironment (named niche) for spermatogonial stem cells (SSCs). They produce amounts of …

Background The genetic causes of human idiopathic non-obstructive azoospermia (NOA) with
meiotic arrest remain unclear. Methods Two Chinese families with infertility participated in …