In the clinical management of paediatric solid tumours, histological examination of tumour
tissue obtained by a biopsy remains the gold standard to establish a conclusive pathological …

The methylation profile of circulating cell-free DNA (cfDNA) in blood can be exploited to
detect and diagnose cancer and other tissue pathologies and is therefore of great diagnostic …

The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest
for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood …

With great interest, we read the paper by Zhou et al.(1) describing a methodology that enables
extracellular RNA sequencing (exRNA-seq) from extremely low input (Small Input Liquid …

PURPOSE Total cell-free DNA (cfDNA) and tumor-derived cfDNA (ctDNA) can be used to
study tumor-derived genetic aberrations. We analyzed the diagnostic and prognostic potential …

Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary
technique for cancer genomic characterization. Since these liquid biopsies will soon be …

Background Paediatric tumours are often characterised by the presence of recurrent DNA
copy number alterations (CNAs). These DNA copy number profiles, obtained from a tissue …

An association between a novel pediatric hyperinflammatory condition and SARS-CoV-2
was recently published and termed pediatric inflammatory multisystem syndrome, temporally …

RNA profiling has emerged as a powerful tool to investigate the biomarker potential of
human biofluids. However, despite enormous interest in extracellular nucleic acids, RNA …

Background and aims Solid tumors account for about 30% of all pediatric cancers. The
diagnosis is typically based on histological and molecular analysis of a primary tumor biopsy. …