Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …

Objective The absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA
sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via …

DEPDC5 mutations have recently been shown to cause epilepsy in humans. Evidence from
in vitro studies has implicated DEPDC5 as a negative regulator of mTORC1 during amino …

Mutations in the GAP activity toward RAGs 1 (GATOR1) complex genes (DEPDC5, NPRL2
and NPRL3) have been associated with focal epilepsy and focal cortical dysplasia (FCD). …

Helicobacter pylori (H. pylori) infection can trigger chronic gastric inflammation perpetuated
by overactivation of the innate immune system, leading to a cascade of precancerous lesions …

Chronic lung diseases including asthma, chronic obstructive pulmonary disease (COPD)
and lung fibrosis represent a major burden on healthcare systems with limited effective …

Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent
Helicobacter pylori (H. pylori) infection. Elevated tyrosine phosphorylation of the latent …

Background & Aims Gastric cancer (GC) is strongly linked with chronic gastritis after Helicobacter
pylori infection. Toll-like receptors (TLRs) are key innate immune pathogenic sensors …

Deregulated activation of the latent transcription factor STAT3 has been implicated in the
pathogenesis of myeloproliferative and lymphoproliferative hematologic disorders. The …

CRISPR-Cas9 gene editing technology has considerably facilitated the generation of
mouse knockout alleles, relieving many of the cumbersome and time-consuming steps of …