Our data reveal an interrelationship between BAP1 and arginine metabolism, providing a
potential means of identifying patients with epithelioid MPM likely to benefit from ADI-PEG20. …

Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release
of ROS and proteases directly causes damage to joints and tissues. Neutrophil function …

Oenocytes are an insect cell type having diverse physiological functions ranging from cuticular
hydrocarbon (CHC) production to insecticide detoxification that may impact their capacity …

The work presented in this thesis explores insecticide resistance using NMR metabolomics
in pupa, early pupa and early adult mosquitoes of both sexes. Firstly, sex differences were …

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical tool that can be
used in the elucidation of chemical structures and is widely applied both in academia and …

Nuclear Magnetic Resonance (NMR) spectroscopy is a widely used analytical technique for
identifying the molecular structure of complex organic compounds. However, NMR data …

Picking peaks in two-dimensional Nuclear Magnetic Resonance (NMR) spectra has been a
critical research problem and a very time-consuming important step in further analyses of …

Background/Aims Janus kinase inhibitors (JAKi) including baricitinib and tofacitinib target
the JAK/STAT pathway and are clinically effective in treating rheumatoid arthritis (RA). …

The work presented in this thesis explored the modification of naturally occurring
nucleosides and is split into two main sections investigating the processes of denitration and …

… As part of my PhD project I ended up working on a metabolomics project and I am incredibly
thankful to Marie Phelan, Rudi Grosman, Susama Chokesuwattanaskul, Caamano Gutierrez…