The sheep genome illuminates biology of the rumen and lipid metabolism

…, DM Muzny, Y Li, W Zhang, JA Stanton, R Brauning… - Science, 2014 - science.org
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent
a distinct class of animals that have a specialized digestive organ, the rumen, that carries …

[HTML][HTML] Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project

…, L Andersson, AL Archibald, CD Bottema, R Brauning… - Genome biology, 2015 - Springer
We describe the organization of a nascent international effort, the Functional Annotation of
Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of …

Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics

…, JC McEwan, R Brauning… - Proceedings of the …, 2009 - National Acad Sciences
The Pecorans (higher ruminants) are believed to have rapidly speciated in the Mid-Eocene,
resulting in five distinct extant families: Antilocapridae, Giraffidae, Moschidae, Cervidae, and …

[HTML][HTML] Construction of relatedness matrices using genotyping-by-sequencing data

KG Dodds, JC McEwan, R Brauning, RM Anderson… - BMC genomics, 2015 - Springer
Background Genotyping-by-sequencing (GBS) is becoming an attractive alternative to array-based
methods for genotyping individuals for a large number of single nucleotide …

Linkage disequilibrium over short physical distances measured in sheep using a high‐density SNP chip

…, R Bunch, R McCulloch, BJ Hayes, R Brauning… - Animal …, 2014 - Wiley Online Library
The extent of linkage disequilibrium ( LD ) between genetic loci has implications for both
association studies and the accuracy of genomic prediction. To characterise the persistence of …

Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases

RR Handley, SJ Reid, R Brauning… - Proceedings of the …, 2017 - National Acad Sciences
The neurodegenerative disorder Huntington’s disease (HD) is typically characterized by
extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, …

[HTML][HTML] Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds

…, A Reverter, M Perez-Enciso, R Brauning… - Nature …, 2018 - nature.com
Domestication fundamentally reshaped animal morphology, physiology and behaviour, offering
the opportunity to investigate the molecular processes driving evolutionary change. Here …

[HTML][HTML] SNPchiMp v. 3: integrating and standardizing single nucleotide polymorphism data for livestock species

…, G Evans, B Simpson, G Tosser-Klopp, R Brauning… - BMC genomics, 2015 - Springer
Background In recent years, the use of genomic information in livestock species for genetic
improvement, association studies and many other fields has become routine. In order to …

[HTML][HTML] A physical map of the bovine genome

…, GL Bennett, IE Bosdet, M Boussaha, R Brauning… - Genome Biology, 2007 - Springer
Background Cattle are important agriculturally and relevant as a model organism. Previously
described genetic and radiation hybrid (RH) maps of the bovine genome have been used …

[HTML][HTML] Whole Genome Sequencing for Determining the Source of Mycobacterium bovis Infections in Livestock Herds and Wildlife in New Zealand

M Price-Carter, R Brauning, GW De Lisle… - Frontiers in Veterinary …, 2018 - frontiersin.org
The ability to DNA fingerprint Mycobacterium bovis isolates helped to define the role of
wildlife in the persistence of bovine tuberculosis in New Zealand. DNA fingerprinting results …