Population balance equations have been used to model a wide range of processes including
polymerization, crystallization, cloud formation, and cell dynamics. Rather than developing …

Sensitivity analysis quantifies the dependence of system behavior on the parameters that
affect the process dynamics. Classical sensitivity analysis, however, does not directly apply to …

In some recent studies, a view emerged that stochastic dynamics governing the switching of
cells from one differentiation state to another could be characterized by a peak in gene …

Motivation Single cell transcriptional profiling opens up a new avenue in studying the
functional role of cell-to-cell variability in physiological processes. The analysis of single cell …

Background Recent advances in molecular biology techniques provide an opportunity for
developing detailed mathematical models of biological processes. An iterative scheme is …

To uncover underlying mechanisms associated with failure of indoleamine 2,3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical …

Advances in sensor technology and increased competition in the pharmaceutical industry
have generated significant interest in the identification of models for the solution formation of …

Kinetic modeling is the most suitable framework to describe the dynamic behavior of mammalian
cell culture although its industrial application is still in its infancy. Herein, the authors …

Emulsion-based crystallization to produce spherical crystalline agglomerates (SAs) is an
attractive route to control crystal size during downstream processing of active pharmaceutical …

10.7554/eLife.50069.001 Alzheimer’s disease (AD) is the most common neurodegenerative
disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a …