Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer’s disease and other types of dementia 1 , yet the …

Background: Type 2 diabetes mellitus (DM) and obesity independently increase the risk of
heart failure by incompletely understood mechanisms. We propose that hyperinsulinemia …

Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long
distances and organizes the intracellular microtubule (MT) network. How dynein motor …

Tau is an intrinsically disordered microtubule-associated protein (MAP) implicated in
neurodegenerative disease. On microtubules, tau molecules segregate into two kinetically distinct …

The regulation of cell physiology depends largely upon interactions of functionally distinct
proteins and cellular components. These interactions may be transient or long-lived, but often …

Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and
organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau …

Protein motion is defined by a network of interactions within the cellular environment, serving
as a direct report of activity and function. The key challenges in single particle tracking (SPT…

Tau is an abundant microtubule-associated protein (MAP) in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other dementias, yet the …

Microtubules (MT) are essential cytoskeletal components for all eukaryotic cell survival. They
are both passive and active participants in all cellular processes ranging from intracellular …