The generation of cell-mediated immunity against many infectious pathogens involves the
production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many …

Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial
pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate …

Platelets have a crucial role in the maintenance of normal haemostasis, and perturbations of
this system can lead to pathological thrombus formation and vascular occlusion, resulting in …

Vertebrates and invertebrates initiate a series of defence mechanisms following infection by
Gram-negative bacteria by sensing the presence of lipopolysaccharide (LPS), a major …

The innate immune system uses Toll family receptors to signal for the presence of microbes
and initiate host defense. Bacterial lipoproteins (BLPs), which are expressed by all bacteria, …

We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP
pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a …

The dominant cone-rod dystrophy gene CORD6 has previously been mapped to within an 8
cM interval on chromosome 17p12-p13. The retinal-specific guanylate cyclase gene (…

Vascular endothelial cells (EC) play a key role in a variety of pathophysiologic processes,
such as angiogenesis, inflammation, cancer metastasis, and vascular diseases. As part of a …

The cDNAs for two membrane guanylyl cyclases, designated E (GC-E) and F (GC-F, were
isolated from a rat eye cDNA library. Their deduced topographic structures correspond to …

Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates
NF-κB. Here, we investigate further the events triggered by TLR2 in response to LPS. We …