Identification of prognostic phenotypes of esophageal adenocarcinoma in 2 independent cohorts

…, JB Kisiel, Y Qin, DA Ahlquist, AK Rustgi, RJ Costa… - Gastroenterology, 2018 - Elsevier
Background & Aims Most patients with esophageal adenocarcinoma (EAC) present with de
novo tumors. Although this could be due to inadequate screening strategies, the precise …

Hybrid asexuality as a primary postzygotic barrier between nascent species: On the interconnection between asexuality, hybridization and speciation

…, J Pačes, H Wilkinson‐Herbots, RJ Costa… - Molecular …, 2018 - Wiley Online Library
Although sexual reproduction is ubiquitous throughout nature, the molecular machinery
behind it has been repeatedly disrupted during evolution, leading to the emergence of asexual …

Inference of gene flow in the process of speciation: An efficient maximum-likelihood method for the isolation-with-initial-migration model

RJ Costa, H Wilkinson-Herbots - Genetics, 2017 - academic.oup.com
The isolation-with-migration (IM) model is commonly used to make inferences about gene
flow during speciation, using polymorphism data. However, it has been reported that the …

Inference of gene flow in the process of speciation: efficient maximum-likelihood implementation of a generalised isolation-with-migration model

RJ Costa, HM Wilkinson-Herbots - Theoretical Population Biology, 2021 - Elsevier
The ‘isolation with migration’ (IM) model has been extensively used in the literature to detect
gene flow during the process of speciation. In this model, an ancestral population split into …

The Generalised Isolation-With-Migration Model: a Maximum-Likelihood Implementation for Multilocus Data Sets

RJ Costa, H Wilkinson-Herbots - arXiv preprint arXiv:1602.01672, 2016 - arxiv.org
Statistical inference about the speciation process has often been based on the isolation-with-migration
(IM) model, especially when the research aim is to learn about the presence or …

Efficient Maximum-Likelihood Inference For The Isolation-With-Initial-Migration Model With Potentially Asymmetric Gene Flow

RJ Costa, H Wilkinson-Herbots - arXiv preprint arXiv:1601.03684, 2016 - arxiv.org
The isolation-with-migration (IM) model is a common tool to make inferences about the
presence of gene flow during speciation, using polymorphism data. However, Becquet and …

Hybrid asexuality as a primary reproductive barrier: on the interconnection between asexuality and speciation

…, J Pačes, H Wilkinson-Herbots, RJ Costa, J Roslein… - bioRxiv, 2016 - biorxiv.org
Speciation usually proceeds in a continuum from intensively hybridizing populations until the
formation of irreversibly isolated species. Restriction of interspecific gene flow may often be …

[PDF][PDF] Complementary contributions of striatal projection pathways to action initiation and execution

F Tecuapetla, X Jin, SQ Lima, RM Costa - Cell, 2016 - cell.com
The performance of an action relies on the initiation and execution of appropriate movement
sequences. Two basal ganglia pathways have been classically hypothesized to regulate …

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

JT Costa, M Mele, MS Baptista, JR Gomes… - Molecular …, 2016 - Springer
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous
system, and changes in GABAergic neurotransmission modulate the activity of neuronal …

The quantification of sodium in mineral waters using a quartz crystal microbalance

MTSR Gomes, JRML Costa, JABP Oliveira - Talanta, 2003 - Elsevier
A sensor for sodium based on a piezoelectric quartz crystal is proposed. The quartz crystal
was coated with 5% of bis[(12-crown-4)methyl] dodecylmethylmalonate, 33% of PVC and 62…