Circular RNAs (circRNAs) have been implicated in cancer progression through largely
unknown mechanisms. Herein, we identify an N 6 -methyladenosine (m 6 A) modified circRNA, …

An effective blood-based method for the diagnosis and prognosis of hepatocellular carcinoma
(HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying cancer-…

N 6 -methyladenosine (m 6 A) modification is an important mechanism in miRNA processing
and maturation, but the role of its aberrant regulation in human diseases remained unclear. …

Cancer is the leading cause of death in China and depicting the cancer pattern of China
would provide basic knowhows on how to tackle it more effectively. In this study we have …

Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are
ubiquitous across species ranging from viruses to mammals. Important advances have been …

Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect)
due in part to mitochondrial respiration injury and hypoxia, which are frequently associated …

Importance Standard first-line therapy for advanced or metastatic esophageal carcinoma is
chemotherapy, but the prognosis remains poor. Camrelizumab (an anti–programmed death …

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …

Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal
squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), …

Gemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for
recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double-blind…