Astrocytic Ca 2+ signaling has been intensively studied in health and disease but has not
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …

Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here,
we provide evidence that brain swelling triggers Ca 2+ signaling in astrocytes and that …

Perivascular spaces are important highways for fluid and solute transport in the brain enabling
efficient waste clearance during sleep. However, the underlying mechanisms augmenting …

Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of dementia that may be
successfully treated with cerebrospinal fluid (CSF) diversion. Recently, magnetic resonance …

To date, it has been difficult to reveal physiological Ca 2+ events occurring within the fine
astrocytic processes of mature animals. The objective of the study was to explore whether …

Cortical spreading depression is a slowly propagating wave of near-complete depolarization
of brain cells followed by temporary suppression of neuronal activity. Accumulating …

Epilepsy is one of the most common neurological disorders – estimated to affect at least 65
million worldwide. Most of the epilepsy research has so far focused on how to dampen …

Aquaporin‐4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes
and ependymal cells. In rodents AQP4 is highly polarized to perivascular astrocytic endfeet …

Epileptic seizures are associated with increased astrocytic Ca 2+ signaling, but the fine
spatiotemporal kinetics of the ictal astrocyte–neuron interplay remains elusive. By using 2-…

Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models,
but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in …