User profiles for Rune Hartmann
Rune hartmannProfessor, Aarhus Universitet Verified email at mbg.au.dk Cited by 11830 |
[HTML][HTML] Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann - Nature immunology, 2015 - nature.com
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas
type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them …
type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them …
[HTML][HTML] OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
Recent discoveries in the field of innate immunity have highlighted the existence of a family
of nucleic acid-sensing proteins that have similar structural and functional properties. These …
of nucleic acid-sensing proteins that have similar structural and functional properties. These …
The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities
…, P Despres, R Hartmann - Journal of Interferon & …, 2011 - liebertpub.com
The 2′-5′ oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes
that recognize virally produced dsRNA and initiate RNA destabilization through activation of …
that recognize virally produced dsRNA and initiate RNA destabilization through activation of …
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
…, V Wagner, SB Rasmussen, R Hartmann… - Journal of …, 2006 - Am Soc Microbiol
Double-stranded RNA (dsRNA) longer than 30 bp is a key activator of the innate immune
response against viral infections. It is widely assumed that the generation of dsRNA during …
response against viral infections. It is widely assumed that the generation of dsRNA during …
Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the …
Type III interferon (IFN) is a novel member of the interferon family. Type III IFN utilizes a receptor
complex different from that of type I IFN, but both types of IFN induce STAT1, STAT2, and …
complex different from that of type I IFN, but both types of IFN induce STAT1, STAT2, and …
An important role for type III interferon (IFN-λ/IL-28) in TLR-induced antiviral activity
…, C Bartholdy, P Staeheli, R Hartmann… - The Journal of …, 2008 - journals.aai.org
Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities, which remain
poorly characterized. We herein show that most cell types expressed both types I and III …
poorly characterized. We herein show that most cell types expressed both types I and III …
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
…, P Serbinowski, R Hartmann… - Nature …, 2006 - nature.com
Nonspecific effects triggered by small interfering RNAs (siRNAs) complicate the use of RNA
interference (RNAi) to specifically downregulate gene expression 1 , 2 , 3 , 4 , 5 . To uncover …
interference (RNAi) to specifically downregulate gene expression 1 , 2 , 3 , 4 , 5 . To uncover …
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
…, TM McCabe, HH Gad, SL Priestnall, R Hartmann… - Science, 2020 - science.org
Excessive cytokine signaling frequently exacerbates lung tissue damage during respiratory
viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced antiviral …
viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced antiviral …
[HTML][HTML] Inhibition of SARS–CoV-2 by type I and type III interferons
U Felgenhauer, A Schoen, HH Gad, R Hartmann… - Journal of Biological …, 2020 - ASBMB
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2) is
the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the …
the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the …
[HTML][HTML] COVID-19 and emerging viral infections: The case for interferon lambda
…, JE Durbin, JS Glenn, R Hartmann… - Journal of Experimental …, 2020 - rupress.org
With the first reports on coronavirus disease 2019 (COVID-19), which is caused by the novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the scientific community …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the scientific community …