Cells employ highly dynamic signaling networks to drive biological decision processes.
Perturbations to these signaling networks may attract cells to new malignant signaling and …

A great challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …

To more effectively target complex diseases like cancer, diabetes and schizophrenia, we may
need to rethink our strategies for drug development and the selection of molecular targets …

We propose a normalization of symbols and terms used to describe, accurately and succinctly,
the detailed interactions between amino acid residues of pairs of interacting proteins at …

A major challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …

Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …

Abstract Changes in the biochemical wiring of oncogenic cells drives phenotypic transformations
that directly affect disease outcome. Here we examine the dynamic structure of the …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to
different sequence segments combine to create a complex function for the whole protein. …

Tumour metastasis is a complex process involving reciprocal interplay between cancer cells
and host stroma at both primary and secondary sites, and is strongly influenced by …