Polycythemia vera (PV) is a human clonal hematological disorder. The molecular etiology of
the disease has not been identified. PV hematopoietic progenitor cells exhibit …

The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting
protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 …

Mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene have been shown to
cause autosomal recessive polycystic kidney disease (ARPKD), but the cellular functions of …

RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork
protection. Defects in these functions cause genomic instability and tumorigenesis but also …

Abasic sites are one of the most common DNA lesions. All known abasic site repair
mechanisms operate only when the damage is in double-stranded DNA. Here, we report the …

We have cloned a novel cell-surface protein designated SPAP1a for S H2 domain-containing
p hosphatase a nchor p rotein 1a. SPAP1a belongs to the group of type I transmembrane …

The DNA damage response kinases ataxia telangiectasia-mutated (ATM), DNA-dependent
protein kinase (DNA-PK), and ataxia telangiectasia-mutated and Rad3-related (ATR) signal …

Cyclin‐dependent kinase 9 (CDK9) is a well‐characterized subunit of the positive transcription
elongation factor b complex in which it regulates transcription elongation in cooperation …

The SMARCAL1 (SWI/SNF related, matrix-associated, actin-dependent, regulator of
chromatin, subfamily A-like 1) DNA translocase is one of several related enzymes, including …

Replication-coupled DNA repair and damage tolerance mechanisms overcome replication
stress challenges and complete DNA synthesis. These pathways include fork reversal, …