Patients with preexisting hypertension, diabetes, coronary heart disease, cerebrovascular
disease, chronic obstructive pulmonary disease (COPD), and kidney dysfunction (…

Background Dynamic D-dimer level is a key biomarker for the severity and mortality of
COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the clinical …

Background Acute lung injury (ALI) is characterized by suppressed fibrinolytic activity in
bronchoalveolar lavage fluid (BALF) attributed to elevated plasminogen activator inhibitor-1 (PAI-…

Smoke-inhalation-induced acute lung injury (SI-ALI) is a leading cause of morbidity and
mortality in victims of fire tragedies. SI-ALI contributes to an estimated 30% of burn-caused …

COVID-19, SARS, and MERS are featured by suppressed lung fibrinolysis. The primary
objective of this study was to decipher the role of the fibrinolytic niche in the progenitor alveolar …

Plasminogen activator inhibitor 1 (PAI-1) level is extremely elevated in the edematous fluid
of acutely injured lungs and pleurae. Elevated PAI-1 specifically inactivates pulmonary …

Background and Purpose Lung oedema in association with suppressed fibrinolysis is a
hallmark of lung injury. Here, we have tested whether plasmin cleaves epithelial sodium …

Failure to regenerate injured alveoli functionally and promptly causes a high incidence of
fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-…

The fourth subunit of the epithelial sodium channel, termed delta subunit (δ ENaC), was cloned
in human and monkey. Increasing evidence shows that this unique subunit and its splice …

… Dr Runzhen Zhao had full access to the data and will vouch for the integrity of the data
analysis. Dr Runzhen Zhao: contributed to the conception and design of the study; acquisition, …