User profiles for Ruoxuan Sun

Ruoxuan Sun

Takeda Pharmaceuticals USA
Verified email at takeda.com
Cited by 285

[HTML][HTML] Glycosylation of immune receptors in cancer

R Sun, AMJ Kim, SO Lim - Cells, 2021 - mdpi.com
Evading host immune surveillance is one of the hallmarks of cancer. Immune checkpoint
therapy, which aims to eliminate cancer progression by reprogramming the antitumor immune …

Optical properties of chemical vapor deposition-grown PtSe2 characterized by spectroscopic ellipsometry

…, D Zhang, XQ Yan, M Ren, X Zhao, F Liu, R Sun… - 2D …, 2019 - iopscience.iop.org
PtSe 2, an emerging 2D group-10 transition metal dichalcogenide (TMD), has aroused
significant attention recently due to its intriguing physical properties. Here, the optical properties …

Saccharide analog, 2‐deoxy‐d‐glucose enhances 4‐1BB‐mediated antitumor immunity via PD‐L1 deglycosylation

B Kim, R Sun, W Oh, AMJ Kim… - Molecular …, 2020 - Wiley Online Library
Triple‐negative breast cancer (TNBC) lacks a well‐defined molecular target and is associated
with poorer outcomes compared to other breast cancer subtypes. Programmed cell death …

Improved Interfacial Ion Migration and Deposition through the Chain‐Liquid Synergistic Effect by a Carboxylated Hydrogel Electrolyte for Stable Zinc Metal Anodes

C Tian, J Wang, R Sun, T Ali, H Wang… - Angewandte Chemie …, 2023 - Wiley Online Library
The large‐scale applicability of Zn‐metal anodes is severely impeded by the issues such as
the dendrite growth, complicated hydrogen evolution, and uncontrollable passivation …

[HTML][HTML] Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity

X Zheng, W Ma, R Sun, H Yin, F Lin, Y Liu, W Xu… - Redox biology, 2018 - Elsevier
Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year
survival rate remains low and chemoprevention has become a strategy to reduce disease …

Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation

…, G Zhang, Y Su, Q Wang, Q Wang, Y Wang, R Sun… - …, 2021 - Elsevier
Increasing evidence indicates that gut microbiota and its metabolites can influence the brain
function and the related behaviors. Trimethylamine N-oxide (TMAO), an indirect metabolite …

The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen

X Zheng, Y Chen, M Bai, Y Liu, B Xu, R Sun… - Free Radical Biology and …, 2019 - Elsevier
Treating cancer metastasis is of vital importance to prolong patients’ survival. Thioredoxin
reductase (TrxR) is overexpressed in many cancer types and has been recognized as an anti-…

[HTML][HTML] Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress

C Dong, L Zhang, R Sun, J Liu, H Yin, X Li, X Zheng… - Scientific reports, 2016 - nature.com
Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant
enzyme. On the other hand, overexpression of TrxR1 is closely correlated with the initiation of …

[HTML][HTML] Thioredoxin reductase as a novel and efficient plasma biomarker for the detection of non-small cell lung cancer: a large-scale, multicenter study

S Ye, X Chen, Y Yao, Y Li, R Sun, H Zeng, Y Shu… - Scientific reports, 2019 - nature.com
There is an increased demand for efficient biomarkers for the diagnosis of non-small cell
lung cancer (NSCLC). This study aimed to evaluate plasma levels of TrxR activity in a large …

Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation

X Zheng, Y Zhang, L Zhang, W Xu, W Ma, R Sun… - Biomedicine & …, 2016 - Elsevier
Sunitinib, a multi-targeted tyrosine kinase inhibitor, has been widely used in the therapy of
advanced renal cell cancer and imatinib-resistant gastrointestinal stromal tumors. However, …