Single-molecule spatial transcriptomics protocols based on in situ sequencing or
multiplexed RNA fluorescent hybridization can reveal detailed tissue organization. However, …

RNA velocity has enabled the recovery of directed dynamic information from single‐cell
transcriptomics by connecting measurements to the underlying kinetics of gene expression. This …

Understanding cell types and mechanisms of dental growth is essential for reconstruction
and engineering of teeth. Therefore, we investigated cellular composition of growing and non-…

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the
main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-…

Biological mechanisms underlying human germline mutations remain largely unknown. We
statistically decompose variation in the rate and spectra of mutations along the genome …

Mutation rate varies along the human genome, and part of this variation is explainable by
measurable local properties of the DNA molecule. Moreover, mutation rates differ between …

Spatial transcriptomics is an emerging stack of technologies, which adds spatial dimension
to conventional single-cell RNA-sequencing. New protocols, based on in situ sequencing or …

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) lumen due to the
disruption of the homeostatic system of the ER leads to the induction of the ER stress …

Replication timing is an important determinant of germline mutation patterns, with a higher
rate of point mutations in late replicating regions. Mechanisms underlying this association …

Motivation: During the past decade, new classes of non-coding RNAs (ncRNAs) and their
unexpected functions were discovered. Stable secondary structure is the key feature of many …