High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate the
dense meshwork of axons, dendrites, and synapses that form neuronal circuits 1 . However…

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from ∼250
× 140 × 90 μm 3 of electron microscopic images, including pyramidal and non-…

To understand the brain we must relate neurons’ functional responses to the circuit architecture
that shapes them. Here, we present a large functional connectomics dataset with dense …

Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological,
molecular, and connectivity signatures. While considerable work has measured the average …

Electron microscopy (EM) is widely used for studying cellular structure and network
connectivity in the brain. We have built a parallel imaging pipeline using transmission electron …

Synapses between excitatory neurons in the cortex and hippocampus are typically made onto
spines, tiny thorn-like protrusions from dendrites (Yuste, 2010). In the 2000s, long-term in …

Mammalian cortex features a large diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity rules powerfully shape …

We present a semi-automated reconstruction of L2/3 mouse primary visual cortex from 3
million cubic microns of electron microscopic images, including pyramidal and inhibitory …

The activity and connectivity of inhibitory cells has a profound impact on the operation of
neuronal networks. While the average connectivity of many inhibitory cell types has been …