Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB,
NFAT, and AP-1. In this study, using the calcium ionophore ionomycin and/or PMA on Jurkat T …

Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine
propagation in the constrained environment of a tissue. In macrophage populations, TLR4 …

The NF-κB transcription regulation system governs a diverse set of responses to various
cytokine stimuli. With tools from in vitro biochemical characterizations, to omics-based whole …

The diagnosis of latent tuberculosis (TB) infection (LTBI) is critical to improve TB treatment
and control, and the T-SPOT.TB test is a commercial enzyme-linked immunosorbent spot …

Our immune system must be able to rapidly fight against pathogens, but at the same time be
tightly regulated to prevent harmful autoimmune and inflammatory responses. This intricate …

The apoptotic caspases are proteases that mediate the process of programmed cell death.
Canonically, their activation is a point of no return; however, the disruption of myoblast …

As CLP editorial advisory board (EAB) Member Rachele Moore, MBA, MLS (ASCP), notes,
demand isn't the only reason we're facing a dearth of new laboratorians, and the solution isn't …

Tuberculosis (TB) is a severe global threat killing more than one million people annually (WHO).
With a successful TB control programme in place, there has been a decrease in the …

Intestinal dwelling parasites live in close association with the complex microbiota that inhabit
our intestinal tracts. The intestinal helminth, Trichuris muris, depends on these bacteria for …