Many viruses induce hepatitis in humans, highlighting the need to understand the underlying
mechanisms of virus-induced liver pathology. The murine coronavirus, mouse hepatitis …

Efficient and productive virus infection often requires viral countermeasures that block
innate immunity. The IFN-inducible 2′,5′-oligoadenylate (2-5A) synthetases (OASs) and …

Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic
human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-…

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome
coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show …

Infection with the murine coronavirus mouse hepatitis virus (MHV) activates the pattern
recognition receptors melanoma differentiation-associated gene 5 (MDA5) and Toll-like receptor …

The inflammasome, a cytosolic protein complex that mediates the processing and secretion
of pro-inflammatory cytokines, is one of the first responders during viral infection. The …

PURPOSE: Artificial sweeteners augment bladder contraction. We hypothesized that
artificial sweeteners activate sweet taste receptors in the bladder. Thus, we investigated the …

Coronaviruses (CoVs) are positive-sense RNA viruses that infect numerous mammalian
and avian species and are capable of causing severe and lethal disease in humans. CoVs …

Previous studies have demonstrated that mouse hepatitis virus (MHV) hepatotropism is
determined largely by postentry events rather than by availability of the viral receptor. In addition, …

Previous studies have demonstrated that the murine coronavirus mouse hepatitis virus (MHV)
nonstructural protein 2 (ns2) is a 2′,5′-phosphodiesterase that inhibits activation of the …