We identified two novel mouse mutants with abnormal head-shaking behavior and neural
tube defects during the course of independent ENU mutagenesis experiments. The …

The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here
we demonstrate that increased stability of Xist RNA is the primary determinant of …

The putative transcription factor ZIC2 is associated with a defect of forebrain development,
known as Holoprosencephaly (HPE), in humans and mouse, yet the mechanism by which …

The Zic genes encode zinc finger containing proteins that can bind proteins and DNA. The
understanding of Zic molecular networks has been hampered by functional redundancy …

The generation of an embryonic body plan is the outcome of inductive interactions between
the progenitor tissues that underpin their specification, regionalization and morphogenesis. …

… Author links open overlay panel Ruth M Arkell 1 , Nicolas Fossat 2 3 , Patrick PL Tam 2 3 …
(t), diencephalon (d) and mesencephalon (m) are to be found are delineated by dashed lines …

The ribosome is an evolutionarily conserved organelle essential for cellular function.
Ribosome construction requires assembly of approximately 80 different ribosomal proteins (RPs) …

Most mouse genetics laboratories maintain mouse strains that require genotyping in order
to identify the genetically modified animals. The plethora of mutagenesis strategies and …

… Barratt, Jacob Souopgui, Sabine Tejpar, Ruth M. Arkell, Zic2 mutation causes holoprosencephaly
via disruption of NODAL signalling, Human Molecular Genetics, Volume 25, Issue 18, …

Flightless I (Flii) is an actin-remodeling protein that influences diverse processes including
cell migration and gene transcription and links signal transduction with cytoskeletal regulation…