Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast
neurotransmission throughout the nervous system. The molecular processes of neurotransmitter …

Rat liver mitochondria were isolated by a combination of differential and Percoll gradient
centrifugation, resulting in a highly pure and intact preparation, as assessed by marker enzyme …

Chemical and biological labeling is fundamental for the elucidation of the function of proteins
within biochemical cellular networks. In particular, fluorescent probes allow detection of …

The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses
following microbial infection, cellular stress and cancer 1 . Upon activation by double-stranded …

5-HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

The lateral organization of a prototypical G protein-coupled receptor, the neurokinin-1 receptor
(NK1R), was investigated in living cells by fluorescence resonance energy transfer (FRET…

Human genetic studies have revealed an association between GTP cyclohydrolase 1
polymorphisms, which decrease tetrahydrobiopterin (BH4) levels, and reduced pain in patients. …

Understanding cellular signaling mediated by cell surface receptors is key to modern
biomedical research and drug development. The discovery of a growing number of potential …

A major contemporary concern in developing effective liposome–nanoparticle hybrids is the
present inclusion size limitation of nanoparticles between vesicle bilayers, which is …

The disulfide bonds that form between two cysteine residues are important in defining and
rigidifying the structures of proteins and peptides. In polypeptides containing multiple cysteine …