User profiles for Ryan A. Melnyk

Ryan A. Melnyk

Berkeley Lab
Verified email at lbl.gov
Cited by 2002

Mutant phenotypes for thousands of bacterial genes of unknown function

…, M Callaghan, J Ray, H Liu, JV Kuehl, RA Melnyk… - Nature, 2018 - nature.com
One-third of all protein-coding genes from bacterial genomes cannot be annotated with a
function. Here, to investigate the functions of these genes, we present genome-wide mutant …

Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram-positive bacteria

…, A Gorur, BS Yeo, R Tran, RA Melnyk… - Proceedings of the …, 2012 - National Acad Sciences
Almost nothing is known about the mechanisms of dissimilatory metal reduction by Gram-positive
bacteria, although they may be the dominant species in some environments. …

[HTML][HTML] Toward a mechanistic understanding of anaerobic nitrate-dependent iron oxidation: balancing electron uptake and detoxification

HK Carlson, IC Clark, RA Melnyk… - Frontiers in microbiology, 2012 - frontiersin.org
The anaerobic oxidation of Fe(II) by subsurface microorganisms is an important part of
biogeochemical cycling in the environment, but the biochemical mechanisms used to couple iron …

Convergent gain and loss of genomic islands drive lifestyle changes in plant-associated Pseudomonas

RA Melnyk, SS Hossain, CH Haney - The ISME journal, 2019 - academic.oup.com
Host-associated bacteria can have both beneficial and detrimental effects on host health.
While some of the molecular mechanisms that determine these outcomes are known, little is …

A Genome-Wide Screen Identifies Genes in Rhizosphere-Associated Pseudomonas Required to Evade Plant Defenses

Z Liu, P Beskrovnaya, RA Melnyk, SS Hossain… - MBio, 2018 - Am Soc Microbiol
Pseudomonas fluorescens and related plant root (“rhizosphere”)-associated species
contribute to plant health by modulating defenses and facilitating nutrient uptake. To identify …

[HTML][HTML] Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

MN Price, GM Zane, JV Kuehl, RA Melnyk, JD Wall… - PLoS …, 2018 - journals.plos.org
For many bacteria with sequenced genomes, we do not understand how they synthesize
some amino acids. This makes it challenging to reconstruct their metabolism, and has led to …

Rhizosphere‐associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens

…, CL Wiesmann, LR Shapiro, RA Melnyk… - Molecular …, 2018 - Wiley Online Library
Plant‐associated soil microbes are important mediators of plant defence responses to diverse
above‐ground pathogen and insect challengers. For example, closely related strains of …

Commensal Pseudomonas fluorescens Strains Protect Arabidopsis from Closely Related Pseudomonas Pathogens in a Colonization-Dependent Manner

NR Wang, CL Wiesmann, RA Melnyk, SS Hossain… - MBio, 2022 - Am Soc Microbiol
Plants form commensal associations with soil microorganisms, creating a root microbiome
that provides benefits, including protection against pathogens. While bacteria can inhibit …

Structure and evolution of chlorate reduction composite transposons

IC Clark, RA Melnyk, A Engelbrektson, JD Coates - MBio, 2013 - Am Soc Microbiol
The genes for chlorate reduction in six bacterial strains were analyzed in order to gain insight
into the metabolism. A newly isolated chlorate-reducing bacterium ( Shewanella alga e …

[HTML][HTML] MamO is a repurposed serine protease that promotes magnetite biomineralization through direct transition metal binding in magnetotactic bacteria

DM Hershey, X Ren, RA Melnyk, PJ Browne… - PLoS …, 2016 - journals.plos.org
Many living organisms transform inorganic atoms into highly ordered crystalline materials.
An elegant example of such biomineralization processes is the production of nano-scale …