Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity

…, C Barrington, JT Roberts, SK Wu, R Bettcher… - Science …, 2021 - science.org
Human Polycomb Repressive Complex 2 (PRC2) catalysis of histone H3 lysine 27
methylation at certain loci depends on long noncoding RNAs (lncRNAs). Yet, in apparent …

RNA matchmaking remodels lncRNA structure and promotes PRC2 activity

…, C Barrington, JT Roberts, SK Wu, R Bettcher… - bioRxiv, 2020 - biorxiv.org
Polycomb Repressive Complex 2 (PRC2) contributes to initiation of heterochromatin through
catalysis of histone H3 lysine 27 (H3K27) methylation. Human PRC2 can work productively …

[BOOK][B] Transgenic Expression of RvDsup and HeDsup Is Insufficient to Provide Enhanced Radiation Tolerance in C. elegans

R Bettcher - 2022 - search.proquest.com
Life on Earth has evolved strategies to survive numerous stressors, of which one is radiation.
Like all stresses, survival against radiation is dependent on dose. Initial insights into …

[HTML][HTML] MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

BM Bettcher, R Fitch, MJ Wynn, MA Lalli… - Alzheimer's & Dementia …, 2016 - Elsevier
Introduction MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown
to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines …

Trapped in the wrong theory: Rethinking trans oppression and resistance

TM Bettcher - Signs: Journal of Women in Culture and …, 2014 - journals.uchicago.edu
In this essay, I defend an account of trans oppression and resistance that departs from the
prevailing transgender model. While I show why both the “trapped in the wrong body” model …

Cerebrospinal fluid and plasma levels of inflammation differentially relate to CNS markers of Alzheimer's disease pathology and neuronal damage

BM Bettcher, SC Johnson, R Fitch… - Journal of …, 2018 - content.iospress.com
Inflammatory markers have been shown to predict neurocognitive outcomes in aging adults;
however, the degree to which peripheral markers mirror the central nervous system remains …

[HTML][HTML] Increases in a pro-inflammatory chemokine, MCP-1, are related to decreases in memory over time

BM Bettcher, J Neuhaus, MJ Wynn, FM Elahi… - Frontiers in aging …, 2019 - frontiersin.org
Objective: To determine the longitudinal relationship between monocyte chemotactic protein
1 (MCP-1)/CCL2 and memory function in older adults. Methods: We examined longitudinal …

Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease

BM Bettcher, KE Olson, NE Carlson, BV McConnell… - Neurobiology of …, 2021 - Elsevier
Astrocytes play a formative role in memory consolidation during physiological conditions;
when dysregulated, astrocytes release glial fibrillary acidic protein (GFAP), which has been …

Declines in inflammation predict greater white matter microstructure in older adults

BM Bettcher, K Yaffe, RM Boudreau, J Neuhaus… - Neurobiology of …, 2015 - Elsevier
Protracted systemic inflammation has been associated with adverse effects on cognition and
brain structure and may accelerate neurodegenerative disease processes; however, it is …

A DMS shotgun lipidomics workflow application to facilitate high-throughput, comprehensive lipidomics

B Su, LF Bettcher, WY Hsieh, D Hornburg… - Journal of the …, 2021 - ACS Publications
Differential mobility spectrometry (DMS) is highly useful for shotgun lipidomic analysis because
it overcomes difficulties in measuring isobaric species within a complex lipid sample and …