User profiles for Ryan F. Seipke

Ryan F. Seipke

University of Leeds
Verified email at leeds.ac.uk
Cited by 3660

[HTML][HTML] Minimum information about a biosynthetic gene cluster

…, JA Salas, EK Schmitt, B Scott, RF Seipke… - Nature chemical …, 2015 - nature.com
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

Streptomyces as symbionts: an emerging and widespread theme?

RF Seipke, M Kaltenpoth… - FEMS microbiology …, 2012 - academic.oup.com
Streptomyces bacteria are ubiquitous in soil, conferring the characteristic earthy smell, and
they have an important ecological role in the turnover of organic material. More recently, a …

[HTML][HTML] A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus

J Barke, RF Seipke, S Grüschow, D Heavens, N Drou… - BMC biology, 2010 - Springer
Background Attine ants live in an intensely studied tripartite mutualism with the fungus
Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

…, BL Bilyk, KJ McDowall, RF Seipke… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has brought
prominence to the Streptomycetaceae, a family of Gram-positive bacteria that inhabit both …

[HTML][HTML] A Single Streptomyces Symbiont Makes Multiple Antifungals to Support the Fungus Farming Ant Acromyrmex octospinosus

RF Seipke, J Barke, C Brearley, L Hill, DW Yu… - PLoS one, 2011 - journals.plos.org
Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by
symbiotic Actinobacteria as weedkillers in their fungus gardens. Actinobacterial species …

Thaxtomin biosynthesis: the path to plant pathogenicity in the genus Streptomyces

…, MV Joshi, EG Johnson, RF Seipke… - Antonie Van …, 2008 - Springer
Streptomyces species are best known for their ability to produce a wide array of medically
and agriculturally important secondary metabolites. However, there is a growing number of …

[HTML][HTML] Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants

…, JT Munnoch, R Devine, NA Holmes, RF Seipke… - Chemical …, 2017 - pubs.rsc.org
We report a new Streptomyces species named S. formicae that was isolated from the African
fungus-growing plant-ant Tetraponera penzigi and show that it produces novel pentacyclic …

Streptomyces scabies 87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant–Microbe Interactions

DRD Bignell, RF Seipke… - Molecular plant …, 2010 - Am Phytopath Society
Plant-pathogenic Streptomyces spp. cause scab disease on economically important root and
tuber crops, the most important of which is potato. Key virulence determinants produced by …

[HTML][HTML] Strain-Level Diversity of Secondary Metabolism in Streptomyces albus

RF Seipke - PLoS One, 2015 - journals.plos.org
Streptomyces spp. are robust producers of medicinally-, industrially- and agriculturally-important
small molecules. Increased resistance to antibacterial agents and the lack of new …

Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism

PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
Microbial natural products, particularly those produced by filamentous Actinobacteria, underpin
the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic classes …