How do we ignore a salient, irrelevant stimulus whose location is predictable? A variety of
studies using instructional manipulations have shown that participants possess the capacity to …

Abstract Information within the brain travels from neuron to neuron across billions of synapses.
At any given moment, only a small subset of neurons and synapses are active, but finding …

Key points Phasic activation of M1 muscarinic receptors generates transient inhibition followed
by longer lasting excitation in neocortical pyramidal neurons. Corticopontine neurons in …

Neonatal white matter injury (nWMI) is an increasingly common cause of cerebral palsy that
results predominantly from hypoxic injury to progenitor cells including those of the …

… Ryan, Andrew J. Dorner, Frederick W. Immermann, Margot O'Toole. Many of these authors
also held stock and/or stock options. A patent application was also filed based on this study - …

BACKGROUND: Despite significant advances in the medical management of Crohn’s disease,
many patients will require intestinal resection during their lifetime. It is disappointing that …

Background Existing treatments for asthma are not effective in all patients and disease
exacerbations are common, highlighting the need for increased understanding of disease …

Introduction Design thinking is a human-centred process that aims to identify the needs of
end-users and iteratively develop solutions. Involving end-users in the development and …

Background Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with
neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and …

Importance Meta-analyses of randomized clinical trials have indicated that improved hypertension
control reduces the risk for cognitive impairment and dementia. However, it is unclear …