Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
RJ Quinton, A DiDomizio, MA Vittoria, K Kotýnková… - Nature, 2021 - nature.com
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis
and generating genetically unstable tetraploid cells that fuel tumour development 1 , 2 . …
and generating genetically unstable tetraploid cells that fuel tumour development 1 , 2 . …
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two
predominant growth-control pathways that dictate proper organ development. We therefore …
predominant growth-control pathways that dictate proper organ development. We therefore …
[HTML][HTML] Identification of the kinase STK25 as an upstream activator of LATS signaling
…, IPM Mauricio, MA Vittoria, RJ Quinton… - Nature …, 2019 - nature.com
The Hippo pathway maintains tissue homeostasis by negatively regulating the oncogenic
transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo pathway …
transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo pathway …
Nuclear envelope rupture drives genome instability in cancer
S Lim, RJ Quinton, NJ Ganem - Molecular biology of the cell, 2016 - Am Soc Cell Biol
The nuclear envelope, composed of two lipid bilayers and numerous accessory proteins,
has evolved to house the genetic material of all eukaryotic cells. In so doing, the nuclear …
has evolved to house the genetic material of all eukaryotic cells. In so doing, the nuclear …
Whole-genome doubling in tissues and tumors
MA Vittoria, RJ Quinton, NJ Ganem - Trends in Genetics, 2023 - cell.com
The overwhelming majority of proliferating somatic human cells are diploid, and this genomic
state is typically maintained across successive cell divisions. However, failures in cell …
state is typically maintained across successive cell divisions. However, failures in cell …
[HTML][HTML] S1P1 Threonine 236 phosphorylation mediates the invasiveness of triple-negative breast cancer and sensitivity to FTY720
…, SK Hwang, G Nguyen, W Yu, CK Wong, RJ Quinton… - Cells, 2023 - mdpi.com
Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with a poor prognosis of
triple-negative breast cancer (TNBC). Despite recent evidence that links the S1P receptor 1 …
triple-negative breast cancer (TNBC). Despite recent evidence that links the S1P receptor 1 …
A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation
…, S Lim, V Kacprzak, RJ Quinton… - Molecular biology of …, 2018 - Am Soc Cell Biol
Tetraploid cells, which are most commonly generated by errors in cell division, are genomically
unstable and have been shown to promote tumorigenesis. Recent genomic studies have …
unstable and have been shown to promote tumorigenesis. Recent genomic studies have …
Publisher Correction: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
RJ Quinton, A DiDomizio, MA Vittoria… - …, 2021 - pubmed.ncbi.nlm.nih.gov
… Ryan J Quinton … 1 , Carlos J Ticas … 6 , Neil J Ganem …
CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels
RJ Quinton, NJ Ganem - The Hippo Pathway: Methods and Protocols, 2019 - Springer
The advent of CRISPR has revolutionized genomic engineering, and harnessing its power to
regulate levels of the transcriptional co-activators YAP and TAZ represents an exciting new …
regulate levels of the transcriptional co-activators YAP and TAZ represents an exciting new …
STK25 directly activates LATS1/2 independent of MST/MAP4Ks
…, HM Mustaly, IPM Mauricio, MA Vittoria, RJ Quinton… - bioRxiv, 2018 - biorxiv.org
The Hippo pathway maintains tissue homeostasis by negatively regulating the oncogenic
transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo pathway …
transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo pathway …