Obesity and cancer: inflammation bridges the two
R Kolb, FS Sutterwala, W Zhang - Current opinion in pharmacology, 2016 - Elsevier
… Author links open overlay panel Ryan Kolb 1 , Fayyaz S Sutterwala 6 , Weizhou Zhang 1 2 3
… AS Ryan, DM Berman, BJ Nicklas, M. Sinha, RL Gingerich, GS Meneilly, JM Egan, D. Elahi …
… AS Ryan, DM Berman, BJ Nicklas, M. Sinha, RL Gingerich, GS Meneilly, JM Egan, D. Elahi …
Inflammasomes in cancer: a double-edged sword
R Kolb, GH Liu, AM Janowski, FS Sutterwala… - Protein & …, 2014 - academic.oup.com
Chronic inflammatory responses have long been observed to be associated with various
types of cancer and play decisive roles at different stages of cancer development. …
types of cancer and play decisive roles at different stages of cancer development. …
[HTML][HTML] Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
R Kolb, L Phan, N Borcherding, Y Liu, F Yuan… - Nature …, 2016 - nature.com
Obesity is associated with an increased risk of developing breast cancer and is also associated
with worse clinical prognosis. The mechanistic link between obesity and breast cancer …
with worse clinical prognosis. The mechanistic link between obesity and breast cancer …
[HTML][HTML] Updates on immunotherapy and immune landscape in renal clear cell carcinoma
Simple Summary Clear cell renal cell carcinomas (ccRCC) have several distinct immunological
features, including a high degree of immune infiltration and relatively low mutational …
features, including a high degree of immune infiltration and relatively low mutational …
[HTML][HTML] Obesity and breast cancer: a case of inflamed adipose tissue
R Kolb, W Zhang - Cancers, 2020 - mdpi.com
Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in
postmenopausal women and a worse prognosis for all major breast cancer subtypes …
postmenopausal women and a worse prognosis for all major breast cancer subtypes …
[HTML][HTML] CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and
a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been …
a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been …
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless
of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of …
of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of …
IL-1 signaling in tumor microenvironment
W Zhang, N Borcherding, R Kolb - … : The Role of Interleukins–Part A, 2020 - Springer
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays
a complex, and sometimes contrasting, role in different stages of cancer development. As a …
a complex, and sometimes contrasting, role in different stages of cancer development. As a …
[HTML][HTML] Beneficial and detrimental roles of NLRs in carcinogenesis
AM Janowski, R Kolb, W Zhang… - Frontiers in …, 2013 - frontiersin.org
Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations,
tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by many …
tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by many …
Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells
N Borcherding, D Kusner, R Kolb, Q Xie, W Li, F Yuan… - Cancer research, 2015 - AACR
It is not well understood how paracrine communication between basal and luminal cell
populations in the mammary gland affects tumorigenesis. During ErbB2-induced mammary …
populations in the mammary gland affects tumorigenesis. During ErbB2-induced mammary …