Background— Exercise capacity as measured by peak oxygen uptake (Vo 2 ) is similarly
impaired in patients with heart failure with preserved ejection fraction (HFpEF) and heart failure …

During appendage regeneration in urodeles and teleosts, tissue replacement is precisely
regulated such that only the appropriate structures are recovered, a phenomenon referred to …

Background— Elevated resting pulmonary arterial pressure (PAP) in patients with left
ventricular systolic dysfunction (LVSD) purports a poor prognosis. However, PAP response …

Patients with germline PTEN mutations are at high risk of developing benign and malignant
tumours. We aimed to evaluate the cumulative risk of several types of cancer and of …

Background— Exercise oscillatory ventilation (EOV) is a noninvasive parameter that potently
predicts outcomes in systolic heart failure (HF). However, mechanistic insights into EOV …

Purpose To create a practical desk reference for clinicians focused on the differential diagnosis
of individuals presenting with features that suggest an inherited disorder of connective …

Background The surgical management of complications after total hip arthroplasty (THA)
necessitates accurate identification of the femoral implant manufacturer and model. Automated …

Studies have shown that Nrf2 E79Q/+ is one of the most common mutations found in human
tumors. To elucidate how this genetic change contributes to lung cancer, we compared lung …

We describe the development and application of a novel series of vectors that facilitate
CRISPR-Cas9-mediated genome editing in mammalian cells, which we call CRISPR-Bac. …

Background— In patients with left ventricular systolic dysfunction (LVSD), the rate at which
oxygen uptake (VO 2 ) increases on initiation of exercise is inadequate to match metabolic …