Despite the success of large-scale genome-wide association studies (GWASs) on complex
traits, our understanding of their genetic architecture is far from complete. Jointly modeling …

Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer,
the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of …

Genetic risk prediction is an important goal in human genetics research and precision
medicine. Accurate prediction models will have great impacts on both disease prevention and …

Extensive efforts have been made to understand genomic function through both experimental
and computational approaches, yet proper annotation still remains challenging, especially …

Continuing efforts from large international consortia have made genome-wide epigenomic
and transcriptomic annotation data publicly available for a variety of cell and tissue types. …

Programmed cell death protein 1 (PD-1) immune checkpoint blockade therapy has
revolutionized cancer treatment. Although PD-1 blockade is effective in a subset of patients with …

Background While next-generation sequencing (NGS) costs have plummeted in recent years,
cost and complexity of computation remain substantial barriers to the use of NGS in routine …

Importance Dual anti-HER2 blockade increased the rate of pathologic complete response (pCR)
in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALTTO) …

Purpose: We performed whole-exome sequencing (WES) of pre- and posttreatment cancer
tissues to assess the somatic mutation landscape of tumors before and after neoadjuvant …

Preliminary results from neoadjuvant trials combining immune checkpoint blockade (ICB)
with standardof-care chemotherapy suggest high pathologic complete response rates that …