A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

Wnt signaling is involved in self-renewal and maintenance of hematopoietic stem cells (HSCs);
however, the particular role of noncanonical Wnt signaling in regulating HSCs in vivo is …

Wnt signaling regulates many aspects of vertebrate development and adult stem cells.
Deregulation of Wnt signaling causes development defect and cancer. The signaling is …

The epigenetic regulation of imprinted genes by monoallelic DNA methylation of either maternal
or paternal alleles is critical for embryonic growth and development 1 . Imprinted genes …

Adoptive cell therapies (ACT) based on chimeric antigen receptor (CAR)-modified immune
cells have made great progress with six CAR-T cell products approved by the US FDA for …

Simple Summary Hepatocellular carcinoma is an aggressive cancer with high mortality. The
introduction of immune-checkpoint inhibitors (ICIs) targeting the programmed-cell death 1 …

Although self-renewal is the central property of stem cells, the underlying mechanism
remains inadequately defined. Using a hematopoietic stem and progenitor cell (HSPC)-specific …

The rapid emergence of spatial transcriptomics (ST) technologies is revolutionizing our
understanding of tissue spatial architecture and biology. Although current ST methods, whether …

The cell-cell interactions are fundamental mechanisms of differentiating embryonic tissues.
1 We aimed to model human embryonic development in stem-cell-derived organoids. We …

The scope of this chapter is to introduce the current consensus of hematopoietic stem cell (HSC)
niche biology to bioengineering field so that can apply to regenerative medicine. A …