… Kazuaki Shimamoto, Katsuyuki Ando, Toshiro Fujita, Naoyuki Hasebe, Jitsuo Higaki,
Masatsugu Horiuchi, Yutaka Imai, Tsutomu Imaizumi, Toshihiko Ishimitsu, Masaaki Ito …

The transcriptional factor nuclear factor-κB (NFκB) plays a pivotal role in the coordinated
trans-activation of cytokine and adhesion molecule genes that might be involved in myocardial …

It is postulated that vascular disease involves a disturbance in the homeostatic balance of
factors regulating vascular tone and structure. Recent developments in gene transfer …

Liver cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration,
characterized by diffuse disorganization of the normal hepatic structure of regenerative …

Adult stem cells hold great promise for use in tissue repair and regeneration, and there has
been continuing interest in both the biology and potential therapeutic applications of adult …

The application of DNA technology to regulate the transcription of disease-related genes in
vivo has important therapeutic potentials. The transcription factor E2F plays a pivotal role in …

ABSTRACT. TGF-β is a key mediator in renal fibrosis. Kidney-targeted gene therapy with
anti–TGF-β strategies is expected to have therapeutic potential, but this has been hampered by …

The type 1 angiotensin II (AT1) receptor is well characterized but the type 2 (AT2) receptor
remains an enigma. We tested the hypothesis that the AT2 receptor can modulate the growth …

Objective— The delivery of autologous progenitor cells into ischemic tissue of patients is
emerging as a novel therapeutic option. Here, we report the potential impact of cultured …

Background— Although viral vector systems are efficient to transfect foreign genes into
blood vessels, safety issues remain in relation to human gene therapy. In this study, we …