A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress
in understanding the genetic basis of PD has been significant. So far, highly-penetrant rare …

Over the last two decades, we have witnessed a revolution in the field of Parkinson’s disease
(PD) genetics. Great advances have been made in identifying many loci that confer a risk …

… Which of these activities is critically important for neuronal damage in PD is not resolved, as
… It is noteworthy that MAPT is the only risk locus that is shared between Alzheimer’s disease (…

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

… We suspect this is because of the way UKB utilizes hospital diagnostic codes. EBV, while
a very common exposure, is not usually reported as a cause of hospital admission. This …

… The TMEM175/GAK locus is another known PD locus where two … it is more parsimonious
to assume that a single GWAS peak is the product of a single causal gene in the locus, there is …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …

… –type markers that is more significant than random chance. Each gene of interest is then
assigned to a primary cell type based on its module membership, which is the correlation of the …

Parkinson’s disease is a genetically complex disorder. Multiple genes have been shown to
contribute to the risk of Parkinson’s disease, and currently 90 independent risk variants have …

… Using Mendelian randomization, we found evidence that hyperlipidemia is a causal risk …
This is because the observed association for an SNP is a product of both its own contribution …