User profiles for Sâmia R. L. Joca
 | Samia R JocaProfessor de Farmacologia, FCFRP, Universidade de São Paulo Verified email at usp.br Cited by 5939 |
[HTML][HTML] Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders
Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric
disorders, including anxiety, psychosis, and depression. The mechanisms responsible for …
disorders, including anxiety, psychosis, and depression. The mechanisms responsible for …
Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to
stress and antidepressants are thought to counteract such responses by increasing BDNF (…
stress and antidepressants are thought to counteract such responses by increasing BDNF (…
Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1A receptors
…, FA Moreira, FS Guimarães, SRL Joca - British journal of …, 2010 - Wiley Online Library
Background and purpose: Cannabidiol (CBD) is a non‐psychotomimetic compound from
Cannabis sativa that induces anxiolytic‐ and antipsychotic‐like effects in animal models. …
Cannabis sativa that induces anxiolytic‐ and antipsychotic‐like effects in animal models. …
5‐HT1A receptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
…, RF Tavares, SFS Lisboa, SRL Joca… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Cannabidiol (CBD) is a non‐psychotomimetic compound from
Cannabis sativa which induces anxiolytic‐ and antipsychotic‐like effects in rodents. These …
Cannabis sativa which induces anxiolytic‐ and antipsychotic‐like effects in rodents. These …
Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex
Currently available antidepressants have a substantial time lag to induce therapeutic response
and a relatively low efficacy. The development of drugs that addresses these limitations …
and a relatively low efficacy. The development of drugs that addresses these limitations …
Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats
LBM Resstel, SRL Joca, FA Moreira… - Behavioural brain …, 2006 - Elsevier
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces
anxiolytic-like effects similar to diazepam in animal models of innate aversive behavior. …
anxiolytic-like effects similar to diazepam in animal models of innate aversive behavior. …
Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings
…, MS Machado, R Andreatini, SRL Joca… - Progress in neuro …, 2020 - Elsevier
Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, presents a
rapid and sustained antidepressant effect in clinical and preclinical studies. Regarding …
rapid and sustained antidepressant effect in clinical and preclinical studies. Regarding …
Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors
BACKGROUND AND PURPOSE Epigenetic modifications are thought to play an important
role in the neurobiology of depression. Antidepressant treatment induces histone acetylation …
role in the neurobiology of depression. Antidepressant treatment induces histone acetylation …
[HTML][HTML] Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels
Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in
several neuropsychiatric disorders including depression. CBD treatment has shown …
several neuropsychiatric disorders including depression. CBD treatment has shown …
Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence
Recent evidence has suggested that systemic administration of non-selective NOS inhibitors
induces antidepressant-like effects in animal models. However, the precise involvement of …
induces antidepressant-like effects in animal models. However, the precise involvement of …