INTRODUCTION Over the past two decades, continuous improvements in “omics” technologies
have driven an ever-greater capacity to define the relationships between genetics, …

The manner by which genotype and environment affect complex phenotypes is one of the
fundamental questions in biology. In this study, we quantified the transcriptome—a subset of …

D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially
promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here …

Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However,
systematic approaches to study the role of transcriptional regulators (TRs) in mediating cancer …

Metabolic reprogramming in cancer enhances macromolecule biosynthesis and supports cell
survival. Oncogenic drivers affect metabolism by altering distinct metabolic processes and …

The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 (PFKFB4)
controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 …

Metabolic profiling of cell line collections has become an invaluable tool to study disease
etiology, drug modes of action and to select personalized treatments. However, large-scale in …

We present an analysis of intracellular metabolism by non-targeted, high-throughput metabolomics
profiling of 18 breast cell lines. We profiled >900 putatively annotated metabolite ions …

Cancer cells reprogram their metabolism to support growth and invasion. While previous
work has highlighted how single altered reactions and pathways can drive tumorigenesis, it …

To examine the role of nucleosome occupancy in the evolution of gene expression, we
measured the genome-wide nucleosome profiles of four yeast species, three belonging to the …