User profiles for Sébastien Léon
 | Sebastien LeonGroup leader, Institut Jacques Monod, Paris, France Verified email at ijm.fr Cited by 2644 |
Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding
…, MN McClean, S Bottani, S Léon… - Proceedings of the …, 2013 - National Acad Sciences
Regulation of the cellular volume is fundamental for cell survival and function. Deviations
from equilibrium trigger dedicated signaling and transcriptional responses that mediate water …
from equilibrium trigger dedicated signaling and transcriptional responses that mediate water …
A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis
Endocytosis regulates the plasma membrane protein landscape in response to environmental
cues. In yeast, the endocytosis of transporters depends on their ubiquitylation by the …
cues. In yeast, the endocytosis of transporters depends on their ubiquitylation by the …
[HTML][HTML] Uniqueness of the mechanism of protein import into the peroxisome matrix: transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors
S Léon, JM Goodman, S Subramani - Biochimica et Biophysica Acta (BBA) …, 2006 - Elsevier
Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that
later lost their DNA, it was expected that protein transport into this organelle would have …
later lost their DNA, it was expected that protein transport into this organelle would have …
Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking
N Belgareh-Touzé, S Léon… - Biochemical Society …, 2008 - portlandpress.com
The ubiquitin ligase (E3) Rsp5p is the only member of the Nedd (neural-precursor-cell-expressed,
developmentally down-regulated) 4 family of E3s present in yeast. Rsp5p has several …
developmentally down-regulated) 4 family of E3s present in yeast. Rsp5p has several …
Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation
We characterize the peroxin PpPex20p from Pichia pastoris and show its requirement for
translocation of PTS2 cargoes into peroxisomes. PpPex20p docks at the peroxisomal …
translocation of PTS2 cargoes into peroxisomes. PpPex20p docks at the peroxisomal …
Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana
Recent results are in favour of a role for NFU-like proteins in Fe–S cluster biogenesis. These
polypeptides share a conserved CXXC motif in their NFU domain. In the present study, we …
polypeptides share a conserved CXXC motif in their NFU domain. In the present study, we …
Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins
S Léon, R Haguenauer-Tsapis - Experimental cell research, 2009 - Elsevier
The subcellular localization of plasma membrane proteins, such as receptors and
transporters, must be finely tuned so that they can be readily downregulated in response to …
transporters, must be finely tuned so that they can be readily downregulated in response to …
Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5
10.7554/eLife.03307.001 After endocytosis, membrane proteins can recycle to the cell
membrane or be degraded in lysosomes. Cargo ubiquitylation favors their lysosomal targeting …
membrane or be degraded in lysosomes. Cargo ubiquitylation favors their lysosomal targeting …
Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies
S Léon, Z Erpapazoglou… - Molecular Biology of …, 2008 - Am Soc Cell Biol
The ubiquitylation of membrane proteins destined for the vacuole/lysosome is essential for
their recognition by the endosomal sorting machinery and their internalization into vesicles of …
their recognition by the endosomal sorting machinery and their internalization into vesicles of …
Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms
C Laussel, S Léon - Biochemical Pharmacology, 2020 - Elsevier
Most malignant cells display increased glucose absorption and metabolism compared to
surrounding tissues. This well-described phenomenon results from a metabolic reprogramming …
surrounding tissues. This well-described phenomenon results from a metabolic reprogramming …