Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies

S Lalevée, R Feil - Epigenomics, 2015 - Future Medicine
Editorial Lalevée & Feil an lncRNA named DBE-T is produced from the few remaining, no
longer silenced, repeats. DBE-T RNA interacts with ASH1L, a component of the Trithorax …

[HTML][HTML] Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp)

S Lalevée, YN Anno, A Chatagnon, E Samarut… - Journal of Biological …, 2011 - ASBMB
The nuclear retinoic acid receptors interact with specific retinoic acid (RA) response elements
(RAREs) located in the promoters of target genes to orchestrate transcriptional networks …

[HTML][HTML] Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

…, A Meynert, T Ballinger, MJE Kelder, S Lalevée… - PLoS …, 2018 - journals.plos.org
Genome editing occurs in the context of chromatin, which is heterogeneous in structure and
function across the genome. Chromatin heterogeneity is thought to affect genome editing …

[PDF][PDF] Meg3 non-coding RNA expression controls imprinting by preventing transcriptional upregulation in cis

I Sanli, S Lalevée, M Cammisa, A Perrin, F Rage… - Cell reports, 2018 - cell.com
Although many long non-coding RNAs (lncRNAs) are imprinted, their roles often remain
unknown. The Dlk1-Dio3 domain expresses the lncRNA Meg3 and multiple microRNAs and …

Phosphorylation by PKA potentiates retinoic acid receptor α activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7

…, Y Brelivet, G Bour, S Lalevée… - Proceedings of the …, 2006 - National Acad Sciences
Nuclear retinoic acid receptors (RARs) work as ligand-dependent heterodimeric RAR/retinoid
X receptor transcription activators, which are targets for phosphorylations. The N-terminal …

Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors

G Bour, S Lalevée, C Rochette-Egly - Trends in cell biology, 2007 - cell.com
Nuclear retinoic acid receptors (RARs) are transcriptional transregulators that control the
expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism …

Cyclin H binding to the RARα activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7

G Bour, E Gaillard, N Bruck, S Lalevée… - Proceedings of the …, 2005 - National Acad Sciences
The transcriptional activity of nuclear retinoic acid receptors (RARs), which act as RAR/retinoid
X receptor (RXR) heterodimers, depends on two activation functions, AF-1 and AF-2, …

[HTML][HTML] Vinexin β interacts with the non-phosphorylated AF-1 domain of retinoid receptor γ (RARγ) and represses RARγ-mediated transcription

G Bour, JL Plassat, A Bauer, S Lalevée… - Journal of Biological …, 2005 - ASBMB
Nuclear retinoic acid receptors (RARs) are ligand-dependent transcription factors that
regulate the expression of retinoic acid target genes. Although the importance of RAR …

Phosphorylation control of nuclear receptors

S Lalevée, C Ferry, C Rochette-Egly - Transcription Factors: Methods and …, 2010 - Springer
Most transcription factors including nuclear receptors (NRs) act as sensors of the extracellular
and intracellular compartments. As such, NRs serve as integrating platforms for a variety of …

Vinexinβ, an atypical “sensor” of retinoic acid receptor γ signaling: union and sequestration, separation, and phosphorylation

S Lalevée, G Bour, M Quinternet, E Samarut… - The FASEB …, 2010 - Wiley Online Library
The transcriptional activity of nuclear retinoic acid receptors (RARs) relies on the association/dissociation
of coregulators at the ligand‐binding domain. However, we determined that the …