Members of the soil‐dwelling prokaryotic genus Streptomyces produce many secondary
metabolites, including antibiotics and anti‐tumour agents. Their formation is coupled with the …

One of the most abundant and widely distributed groups of Helix-turn-helix (HTH) transcription
factors is the metabolite-responsive GntR family of regulators (>8500 members in the …

N-Acetylglucosamine, the monomer of chitin, is a favored carbon and nitrogen source for
streptomycetes. Its intracellular catabolism requires the combined actions of the N-…

Cave moonmilk deposits host an abundant and diverse actinobacterial population that has a
great potential for producing novel natural bioactive compounds. In our previous attempt to …

Transcriptional regulation is key in bacteria for providing an adequate response in time and
space to changing environmental conditions. However, despite decades of research, the …

Haydon and Guest (Haydon, D. J, and Guest, JR (1991) FEMS Microbiol. Lett. 63, 291–295)
first described the helix-turn-helix GntR family of bacterial regulators. They presented them …

Members of the soil‐dwelling, sporulating prokaryotic genus Streptomyces are indispensable
for the recycling of the most abundant polysaccharides on earth (cellulose and chitin), and …

In the post-genomic area, the prediction of transcription factor regulons by position weight
matrix-based programmes is a powerful approach to decipher biological pathways and to …

The complete understanding of the morphological differentiation of streptomycetes is an
ambitious challenge as diverse sensors and pathways sensitive to various environmental stimuli …

The availability of nutrients is a major determinant for the timing of morphogenesis and antibiotic
production in the soil‐dwelling bacterium Streptomyces coelicolor. Here we show that N…