Super‐resolution microscopy unveils dynamic heterogeneities in nanoparticle protein corona
N Feiner‐Gracia, M Beck, S Pujals, S Tosi, T Mandal… - Small, 2017 - Wiley Online Library
The adsorption of serum proteins, leading to the formation of a biomolecular corona, is a key
determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge …
determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge …
[HTML][HTML] Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
Intestinal organoids have emerged as a powerful in vitro tool for studying intestinal biology
due to their resemblance to in vivo tissue at the structural and functional levels. However, …
due to their resemblance to in vivo tissue at the structural and functional levels. However, …
A genome editing approach to study cancer stem cells in human tumors
…, M Sevillano, M Aguilera, S Tosi… - EMBO molecular …, 2017 - embopress.org
The analysis of stem cell hierarchies in human cancers has been hampered by the impossibility
of identifying or tracking tumor cell populations in an intact environment. To overcome …
of identifying or tracking tumor cell populations in an intact environment. To overcome …
Light‐regulated stapled peptides to inhibit protein–protein interactions involved in clathrin‐mediated endocytosis
…, K Eckelt, N Camarero, S Tosi… - Angewandte Chemie …, 2013 - Wiley Online Library
Protein–protein interactions (PPIs)[1] are essential in almost every biological process.
Recently, PPIs have emerged as therapeutic targets of interest,[2] and ligands directed to …
Recently, PPIs have emerged as therapeutic targets of interest,[2] and ligands directed to …
[HTML][HTML] Urease-powered nanobots for radionuclide bladder cancer therapy
…, B Yagüe, L Aguado, L Bardia, S Tosi… - Nature …, 2024 - nature.com
Bladder cancer treatment via intravesical drug administration achieves reasonable survival
rates but suffers from low therapeutic efficacy. To address the latter, self-propelled …
rates but suffers from low therapeutic efficacy. To address the latter, self-propelled …
[HTML][HTML] Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein …
Background The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer’s
disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by …
disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by …
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
…, D Byrom, C Cortina, C Morral, C Barceló, S Tosi… - Nature …, 2015 - nature.com
Recent molecular classifications of colorectal cancer (CRC) based on global gene expression
profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon …
profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon …
The P4‐ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
…, C Belmonte‐Mateos, S Sabido‐Bozo, S Tosi… - EMBO …, 2023 - embopress.org
Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that
tether vesicles at the acceptor membrane. Interactions with other components of the trafficking …
tether vesicles at the acceptor membrane. Interactions with other components of the trafficking …
[HTML][HTML] Imaging the cell morphological response to 3D topography and curvature in engineered intestinal tissues
G Altay, S Tosi, M García-Díaz… - Frontiers in bioengineering …, 2020 - frontiersin.org
While conventional cell culture methodologies have relied on flat, two-dimensional cell
monolayers, three-dimensional engineered tissues are becoming increasingly popular. Often, …
monolayers, three-dimensional engineered tissues are becoming increasingly popular. Often, …
[PDF][PDF] BIAFLOWS: A collaborative framework to reproducibly deploy and benchmark bioimage analysis workflows
Image analysis is key to extracting quantitative information from scientific microscopy images,
but the methods involved are now often so refined that they can no longer be …
but the methods involved are now often so refined that they can no longer be …