Super‐resolution microscopy unveils dynamic heterogeneities in nanoparticle protein corona

N Feiner‐Gracia, M Beck, S Pujals, S Tosi, T Mandal… - Small, 2017 - Wiley Online Library
The adsorption of serum proteins, leading to the formation of a biomolecular corona, is a key
determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge …

[HTML][HTML] Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function

G Altay, E Larrañaga, S Tosi, FM Barriga, E Batlle… - Scientific reports, 2019 - nature.com
Intestinal organoids have emerged as a powerful in vitro tool for studying intestinal biology
due to their resemblance to in vivo tissue at the structural and functional levels. However, …

A genome editing approach to study cancer stem cells in human tumors

…, M Sevillano, M Aguilera, S Tosi… - EMBO molecular …, 2017 - embopress.org
The analysis of stem cell hierarchies in human cancers has been hampered by the impossibility
of identifying or tracking tumor cell populations in an intact environment. To overcome …

Light‐regulated stapled peptides to inhibit protein–protein interactions involved in clathrin‐mediated endocytosis

…, K Eckelt, N Camarero, S Tosi… - Angewandte Chemie …, 2013 - Wiley Online Library
Protein–protein interactions (PPIs)[1] are essential in almost every biological process.
Recently, PPIs have emerged as therapeutic targets of interest,[2] and ligands directed to …

[HTML][HTML] Urease-powered nanobots for radionuclide bladder cancer therapy

…, B Yagüe, L Aguado, L Bardia, S Tosi… - Nature …, 2024 - nature.com
Bladder cancer treatment via intravesical drug administration achieves reasonable survival
rates but suffers from low therapeutic efficacy. To address the latter, self-propelled …

[HTML][HTML] Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein …

…, E Radaelli, N Corthout, J Colombelli, S Tosi… - Molecular …, 2017 - Springer
Background The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer’s
disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by …

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

…, D Byrom, C Cortina, C Morral, C Barceló, S Tosi… - Nature …, 2015 - nature.com
Recent molecular classifications of colorectal cancer (CRC) based on global gene expression
profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon …

The P4‐ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast

…, C Belmonte‐Mateos, S Sabido‐Bozo, S Tosi… - EMBO …, 2023 - embopress.org
Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that
tether vesicles at the acceptor membrane. Interactions with other components of the trafficking …

[HTML][HTML] Imaging the cell morphological response to 3D topography and curvature in engineered intestinal tissues

G Altay, S Tosi, M García-Díaz… - Frontiers in bioengineering …, 2020 - frontiersin.org
While conventional cell culture methodologies have relied on flat, two-dimensional cell
monolayers, three-dimensional engineered tissues are becoming increasingly popular. Often, …

[PDF][PDF] BIAFLOWS: A collaborative framework to reproducibly deploy and benchmark bioimage analysis workflows

…, N Sladoje, P Paul-Gilloteaux, R Marée, S Tosi - Patterns, 2020 - cell.com
Image analysis is key to extracting quantitative information from scientific microscopy images,
but the methods involved are now often so refined that they can no longer be …