[PDF][PDF] RIG-I recognizes the 5′ region of dengue and Zika virus genomes
M Chazal, G Beauclair, S Gracias, V Najburg… - Cell reports, 2018 - cell.com
The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika
(ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition receptors that are …
(ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition receptors that are …
Assessment of multiplex digital droplet RT-PCR as a diagnostic tool for SARS-CoV-2 detection in nasopharyngeal swabs and saliva samples
…, P Chambon, F Charbonnier, S Gracias… - Clinical …, 2021 - academic.oup.com
Background Reverse transcription-quantitative PCR on nasopharyngeal swabs is currently
the reference COVID-19 diagnosis method but exhibits imperfect sensitivity. Methods We …
the reference COVID-19 diagnosis method but exhibits imperfect sensitivity. Methods We …
[HTML][HTML] Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti
…, M Berthet, G Moratorio, S Gracias… - PLoS neglected …, 2019 - journals.plos.org
Background To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-borne
viruses have to cross several barriers in the mosquito body, including the midgut …
viruses have to cross several barriers in the mosquito body, including the midgut …
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2
S Gracias, M Chazal, A Decombe, Y Unterfinger… - EMBO …, 2023 - embopress.org
The mechanisms utilized by different flaviviruses to evade antiviral functions of interferons
are varied and incompletely understood. Using virological approaches, biochemical assays, …
are varied and incompletely understood. Using virological approaches, biochemical assays, …
[HTML][HTML] Immature particles and capsid-free viral RNA produced by Yellow fever virus-infected cells stimulate plasmacytoid dendritic cells to secrete interferons
L Sinigaglia, S Gracias, E Décembre, M Fritz… - Scientific Reports, 2018 - nature.com
Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in
response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such …
response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such …
[HTML][HTML] Uncovering flavivirus host dependency factors through a genome-wide gain-of-function screen
Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV)
viruses, are mosquito-borne pathogens that present a major risk to global public health. To …
viruses, are mosquito-borne pathogens that present a major risk to global public health. To …
Retinoic acid inducible gene I and protein kinase R, but not stress granules, mediate the proinflammatory response to yellow fever virus
…, M Chazal, D Bruni, S Lesage, S Gracias… - Journal of …, 2020 - Am Soc Microbiol
Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are
responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory …
responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory …
HIV-1 non-group M phenotypic susceptibility in vitro to bictegravir and cabotegravir
C Martin, S Gracias, C Charpentier… - Journal of …, 2021 - academic.oup.com
Objectives HIV-1 group O (HIV-1/O) is one of the four HIV-1 groups and is endemic in Cameroon,
representing 1% of HIV-1 infections in the population. Around 50% of the strains of this …
representing 1% of HIV-1 infections in the population. Around 50% of the strains of this …
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses
…, M Arnaud‐Arnould, S Gracias, F Garcia de Gracia… - EMBO …, 2022 - embopress.org
Genome‐wide screens are powerful approaches to unravel regulators of viral infections.
Here, a CRISPR screen identifies the RNA helicase DDX42 as an intrinsic antiviral inhibitor of …
Here, a CRISPR screen identifies the RNA helicase DDX42 as an intrinsic antiviral inhibitor of …
A genome-wide CRISPR/Cas9 knock-out screen identifies the DEAD box RNA helicase DDX42 as a broad antiviral inhibitor
…, A Rebendenne, FG de Gracia, J McKellar, S Gracias… - bioRxiv, 2020 - biorxiv.org
Genome-wide CRISPR/Cas9 knock-out genetic screens are powerful approaches to unravel
new regulators of viral infections. Here, we took advantage of the ability of interferon (IFN) …
new regulators of viral infections. Here, we took advantage of the ability of interferon (IFN) …