Neuromuscular dysfunction is prevalent in critically ill patients, is associated with worse
short-term outcomes, and is a determinant of long-term disability in intensive care unit survivors. …

The low productivity and escalating costs of drug development have been well documented
over the past several years. Less than 10% of new compounds that enter clinical trials …

Objective To conduct the first meta-analysis evaluating the internal and external validity of
the sluggish cognitive tempo (SCT) construct as related to or distinct from attention-deficit/…

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …

Context During the 2007-2008 influenza season, oseltamivir resistance among influenza A(H1N1)
viruses increased significantly for the first time worldwide. Early surveillance data …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor
characterized by rapid and uniform patient demise 1 . A heterozygous point mutation of histone …

An increasing number of engineered protein therapeutics are currently being developed,
tested in clinical trials and marketed for use. Many of these proteins arose out of hit-and-miss …

Resistance to contemporary broad-spectrum beta-lactams, mediated by extended-spectrum
beta-lactamase (ESBL) enzymes, is an increasing problem worldwide. The Etest (AB Biodisk…

As is cautioned in many package inserts, ‘with all therapeutic proteins, there is a potential
for immunogenicity’. Immunogenicity problems in humans, which currently can be detected …