To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis of
rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new …

The complete assembly of each human chromosome is essential for understanding human
biology and evolution 1 , 2 . Here we use complementary long-read sequencing …

Highlights • Insect genome assembly is difficult, unreliable and often low quality. • Obstacles
include DNA polymorphism, inability to inbreed and limited DNA quantities. • New short …

Background The duplication of genes can occur through various mechanisms and is thought
to make a major contribution to the evolutionary diversification of organisms. There is …

Background Relatively little is known about the genomic basis and evolution of wood-feeding
in beetles. We undertook genome sequencing and annotation, gene expression assays, …

Around 150 million years ago, eusocial termites evolved from within the cockroaches, 50
million years before eusocial Hymenoptera, such as bees and ants, appeared. Here, we report …

Autism is a highly heritable complex disorder in which de novo mutation (DNM) variation
contributes significantly to risk. Using whole-genome sequencing data from 3,474 families, we …

Bacteria confined to intracellular environments experience extensive genome reduction. In
extreme cases, insect endosymbionts have evolved genomes that are so gene-poor that they …

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite
throughout much of the world during the past two decades. This global resurgence is likely …

INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a representative …