3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-stage
embryos, have emerged as a powerful tool to study the early stages of mammalian …

… We could not detect expression of Fos and Socs3 in cryosections; however, we could
detect Fos in SCs that had undergone dissociation or both dissociation and FACS, which …

The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …

Mouse embryonic stem cells (mESCs) are clonal populations derived from preimplantation
mouse embryos that can be propagated in vitro and, when placed into blastocysts, contribute …

Gastruloids are three-dimensional aggregates of embryonic stem cells that display key
features of mammalian development after implantation, including germ-layer specification and …

… Susanne C van den Brink , Susanne C van den Brink … L Bredenoord, Susana M Chuva
de Sousa Lopes, Susanne C van den Brink, Bernard AJ Roelen, Guido MWR de Wert, Björn …

We have developed a protocol improving current Embryoid Body (EB) culture which allows
the study of self-organization, symmetry breaking, axial elongation and cell fate specification …

Organ laterality refers to the left-right asymmetry in disposition and conformation of internal
organs and is established during embryogenesis. The heart is the first organ to display visible …

… van den Brink4 and Cristina Pina2,3 … SC vdB is funded by an EMBO Postdoctoral Fellowship
(ALTF 195-2021) and … The Authors thank Dr Emile van den Akker for critical reading of the …

… Susanne C van den Brink … 2 , Vincent van Batenburg … scvandenbrink@gmail.com. …