User profiles for S. E. Stasiak
 | Suzanne StasiakPhD Candidate, Department of Bioengineering, Northeastern University Verified email at husky.neu.edu Cited by 103 |
[HTML][HTML] Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling
For an airway or a blood vessel to narrow, there must be a connected path that links the
smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to …
smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to …
Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity
The current therapeutic approach to asthma focuses exclusively on targeting inflammation
and reducing airway smooth muscle force to prevent the recurrence of symptoms. However, …
and reducing airway smooth muscle force to prevent the recurrence of symptoms. However, …
Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells
In this study, we report the existence of a communication system among human smooth
muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An …
muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An …
Extracellular matrix stiffness regulates force transmission pathways in multicellular ensembles of human airway smooth muscle cells
For an airway or a blood vessel to narrow, there must be a connected path that links the
smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to …
smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to …
[PDF][PDF] Increasing Stiffness of Collagen Fibers Can Lead to Excessive Constriction of Airways
It is well understood that airway remodeling in asthma is accompanied by significant changes
in the ECM, including a fibrotic response that results in increased collagen deposition. …
in the ECM, including a fibrotic response that results in increased collagen deposition. …
The Mechanobiology of Airway Narrowing in Asthma
SE Stasiak - 2022 - search.proquest.com
For over 50 years, asthma has been thought of, and treated as a disease of the smooth
muscle brought about by persistent inflammation in the airways. However, even when an …
muscle brought about by persistent inflammation in the airways. However, even when an …
Increasing the Stiffness of the Extracellular Matrix Is a Sufficient Condition for Airway Hyperreactivity
Rationale: Asthma is an inflammatory disease of the airways brought about by persistent
inflammation. Even when inflammation is brought under control, asthmatic airways can still …
inflammation. Even when inflammation is brought under control, asthmatic airways can still …
[PDF][PDF] Collective Mechanosensing Regulates the Agonist-Induced Calcium Response in Smooth Muscle Cells
66-Plat Propagation of Membrane Tension in Neuronal Axons Zheng Shi1, Adam E. Cohen2.
1Chemistry and Chemical Biol, Rutgers University, Piscataway, NJ, USA, 2Chemistry and …
1Chemistry and Chemical Biol, Rutgers University, Piscataway, NJ, USA, 2Chemistry and …
Airway Smooth Muscle Cells Dynamically Change Their Intercellular Coupling During Agonist Exposure
SE Stasiak, DT Tambe… - TP118. TP118 AIRWAY …, 2021 - atsjournals.org
Introduction: For airways to constrict, the smooth muscle cells (SMCs) must form a connected
path that transmits force around the circumference of the airway lumen. The number of cells …
path that transmits force around the circumference of the airway lumen. The number of cells …
A Force-induced Force-generation Mechanism in the Airway Smooth Muscle
Rationale: The airway smooth muscle (ASM) is capable of tonic contractions where it can
hold tension for long durations. The mechanisms that underlie this ability are not well …
hold tension for long durations. The mechanisms that underlie this ability are not well …