The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the
cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural, …

Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology. …

The Premorbid Adjustment Scale (PAS) is a rating scale which was developed to be
applicable in a research setting. It is designed to evaluate the degree of achievement of …

Background: Up-regulation of γ-aminobutyric acid A (GABA A ) receptors and decreased GABA
uptake in the cerebral cortex of schizophrenics suggest altered GABAergic transmission, …

Cholinergic neuron loss is a cardinal feature of Alzheimer disease. Nerve growth factor (NGF)
stimulates cholinergic function, improves memory and prevents cholinergic degeneration …

The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

Schizophrenia is a psychotic disorder characterized by functional dysconnectivity or
abnormal integration between distant brain regions. Recent functional imaging studies have …

Background Aripiprazole is a dopamine D 2 receptor partial agonist with partial agonist
activity at serotonin 5HT 1A receptors and antagonist activity at 5HT 2A receptors. This …

• Epidemiological and anatomical studies support the theory that disturbances of brain
development may play a contributory role in the etiology of schizophrenia. Anatomical findings …