User profiles for S. H. Merkling

Sarah Merkling

Research Faculty, CNRS, Institut Pasteur, Paris
Verified email at pasteur.fr
Cited by 4277

Beyond RNAi: antiviral defense strategies in Drosophila and mosquito

SH Merkling, RP van Rij - Journal of insect physiology, 2013 - Elsevier
Virus transmission and spread by arthropods is a major economic and public health concern.
The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is an …

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

…, F Pène, N Marin, N Roche, TA Szwebel, SH Merkling… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated immune …

[HTML][HTML] Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

…, J Hadjadj, N Yatim, H Pere, SH Merkling… - Nature …, 2021 - nature.com
Coordinated local mucosal and systemic immune responses following severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against coronavirus …

[PDF][PDF] Dicer-2-dependent generation of viral DNA from defective genomes of RNA viruses modulates antiviral immunity in insects

…, H Loyd, LI Levi, S Lanciano, C Baron, SH Merkling… - Cell Host & Microbe, 2018 - cell.com
The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are
amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, …

[HTML][HTML] Dissecting human population variation in single-cell responses to SARS-CoV-2

…, Z Li, M O'Neill, J Mendoza-Revilla, SH Merkling… - Nature, 2023 - nature.com
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection 1 ,
2 – 3 , the genetic and immunological basis of which has begun to be deciphered 4 . …

[PDF][PDF] Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries

…, P Miesen, L Frangeul, AB Crist, SH Merkling… - Current Biology, 2020 - cell.com
Endogenous viral elements (EVEs) are viral sequences integrated in host genomes. A large
number of non-retroviral EVEs was recently detected in Aedes mosquito genomes, leading …

[HTML][HTML] Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study

J Rosado, S Pelleau, C Cockram, SH Merkling… - The Lancet …, 2021 - thelancet.com
Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
induces an antibody response targeting multiple antigens that changes over time. This study …

A satellite repeat-derived piRNA controls embryonic development of Aedes

…, I Rondeel, B Pennings, CBF Vogels, SH Merkling… - Nature, 2020 - nature.com
Tandem repeat elements such as the diverse class of satellite repeats occupy large parts of
eukaryotic chromosomes, mostly at centromeric, pericentromeric, telomeric and subtelomeric …

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

…, EF Miot, D Martynow, A Baidaliuk, SH Merkling… - Science, 2020 - science.org
The drivers and patterns of zoonotic virus emergence in the human population are poorly
understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that …

Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo

…, S Dabo, LB Dickson, F Aubry, SH Merkling… - Journal of …, 2019 - Am Soc Microbiol
Aedes aegypti mosquitoes are the main vectors of arthropod-borne viruses (arboviruses) of
public health significance, such as the flaviviruses dengue virus (DENV) and Zika virus (ZIKV)…