Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of unique …

Anti-NMDA receptor (NMDAR) encephalitis is a newly identified autoimmune disorder that
targets NMDARs, causing severe neurological symptoms including hallucinations, psychosis, …

S-nitrosylation, the selective posttranslational modification of protein cysteine residues to
form S-nitrosocysteine, is one of the molecular mechanisms by which nitric oxide influences …

Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple
sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is …

Rat hearts have been perfused in vitro with 5 mM glucose and either 5 mM acetate or 1 mM
pyruvate to achieve steady state conditions, followed by replacement of the acetate with 90% …

Aims Previous studies have demonstrated improved cardiac function following myocardial
infarction (MI) after administration of endothelial progenitor cells (EPCs) into ischaemic …

The human protein MED1 (also known as MBD4) was previously isolated in a two-hybrid
screening using the mismatch repair protein MLH1 as a bait, and shown to have homology to …

Many of the emerging technologies for the global evaluation of gene expression, at both the
RNA and protein level, are being applied to the problem of finding biomarkers for human …

Viral proteins mimic host protein structure and function to redirect cellular processes and
subvert innate defenses 1 . Small basic proteins compact and regulate both viral and cellular …

Growing appreciation for astrocytes as active participants in nervous system development,
neurovascular metabolic coupling, and neurological disease progression has stimulated …